Oligonucleotide Synthesis Market Production,End User and Application Report 2021

The global oligonucleotide synthesis market is expected to witness significant demand over the forecast period. Oligonucleotides are short nucleic acid polymers used in research, genetic testing and forensics. Oligonucleotides are usually made up of 13 to 25 nucleotides and are designed to hybridize specifically to DNA or RNA sequences. Solid-phase clinical synthesis is used to manufacture these small bits of nucleic acid for use in polymerase chain reaction (PCR), DNA sequencing, library construction and artificial gene synthesis.

Oligonucleotide synthesis is the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure/sequence.In the enzymatic process of DNA synthesis, deoxy-ribonucleotide-5-tri-phosphates are used as substrates during polymerization. In addition, this process requires a primer and a template.

The most frequently used oligonucleotide synthesis strategy is based upon beta-cyanoethylphosphoramidite chemistry. The synthesis proceeds from the 3’ to the 5’ end of the oligonucleotide, which is in opposition to the enzymatically catalyzed reaction where polymerization proceeds from 5’- 3’. The synthesis continues repeating cycle until the sequence of the oligonucleotide has been built.

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Growing R&D spending in pharmaceutical and biotechnology companies, increased use in clinical applications and molecular diagnostics, growing government investments for the development of genomics and developingconsequence of RNA-interference oligos in the therapeutics and diagnostics are the key factors driving market size for oligonucleotide synthesis.

Whereas, high cost of synthesized oligonucleotides and strict regulatory requirements for the approval of oligonucleotide-based therapeutics are some of the factors constraining the growth of the oligonucleotide synthesis market to some extent.

On the basis of product type and services, the oligonucleotide synthesis market is classified into by Product (Synthesized Oligonucleotides, Primers, Probes, Intermediate-scale synthesis Oligos, Large-scale synthesis Oligos, Linkers and Adaptors), By Services (Custom Oligos, Pre-designed Oligos, Reagents, Equipment).Synthesized oligonucleotides segment is expected to account for the largest market share in the forecast period. This is due to the increasing number of applications of synthesized oligonucleotides in research, diagnostics, and therapeutics. The mounting demand for custom oligos also subsidizes to the growth of the synthesized oligonucleotides market.

On the basis of application, the oligonucleotide market is classified into Research, Diagnostics, Therapeutics. Research segment is sub-segmented into PCR, qPCR, DNA Sequencing, Gene Synthesis, other. Therapeutics is further sub-segmented into DNA/Antisense oligo’s, RNA, Nucleic acid aptamers, Immunotherapy Applications.

Research segment accounts for the largest market size of oligonucleotide synthesis market. Diagnostic segment is likely to grow at highest CAGR during the forecast period. This is mainly due to the developing application of molecular diagnostics (MDx) and genetic testing. The growing use of technologies such as DNA microarrays in the analysis of biological samples and developing molecular oncology diagnostics tests also subsidize in the growth of molecular diagnostics market size.

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